"Vertical" Inhibition of HER2 Yields Horizontal Gains in the Clinic.
نویسندگان
چکیده
HER2-targeted therapy has moved beyond trastuzumab to include other monoclonals targeting the cell surface, receptor tyrosine kinase inhibitors of HER2, and antibody-drug conjugates. Afatinib, a small molecule receptor tyrosine kinase inhibitor, now joins the ranks of HER2-targeting agents in combination with trastuzumab. The combination brings new opportunities and challenges.
منابع مشابه
Correction: "Vertical" Inhibition of HER2 Yields Horizontal Gains in the Clinic.
Figure 1. Target domains for combined receptor blockade of HER2. Left, HER2 has an extracellular domain (ECD), a single transmembrane domain (TM), and a cytoplasmic kinase domain (CD). The dimerization loop of HER2 is indicated by the dashed circle, and small green circles indicate segments for which the crystal structures have not yet been solved. On the upper right is a space-filling model of...
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ورودعنوان ژورنال:
- Clinical cancer research : an official journal of the American Association for Cancer Research
دوره 21 12 شماره
صفحات -
تاریخ انتشار 2015